A New Larvicidal Lignan from Piper fimbriulatum.

Abstract

A new lignan, 3,4,5′-trimethoxy-3′,4′-methylenedioxy-7,9′:7′,9 diepoxylignan (1) (6-4-(3,4-dimethoxy-phenyl)-tetrahydro-furo3,4-c.]furan-1-yl]-4-methoxy-benzo] dioxole) together with two known lignans, 7′-epi.-sesartemin (2) and diayangambin (3), and a known flavonoid, 5-hydroxy-7,4′-dimethoxyflavone (4), were isolated from the leaves of Piper fimbriulatum. C. DC. Their structures were assigned by a combination of one- and two-dimensional NMR techniques. 7′-epi.-Sesartemin (2) showed the highest larvicidal activity against Aedes aegypti. (LC₁₀₀ 17.6 µg/ml) and weak antiplasmodial (IC₅₀ 7.0 µg/ml) and antitrypanosomal (IC₅₀ 39.0 µg/ml) activities. None of the compounds was active against Leishmania mexicana..