Release and effects of calcitonin gene-related peptide in myocardial ischaemia

This thesis is based on the following papers, which will be referred to by their Roman numerals. I. Franco-Cereceda A, Källner G, Lundberg JM: Capsazepine-sensitive release of calcitonin gene-related peptide from C-fibre afferents in the guinea-pig heart by low pH and lactic acid. Eur J Pharmacol 1993;238:311-316. II. Franco-Cereceda A, Källner G, Lundberg JM: Cyclo-oxygenase products released by low pH have capsaicin-like actions on sensory nerves in the isolated guinea pig heart. Cardiovasc Res 1994;28:365-369. III. Källner G, Franco-Cereceda A: Attenuation of low pH-, but not capsaicin- or PGI-evoked CGRP-release by endothelium removal using saponin. Acta Physiol Scand 1995;155:251-256. IV. Källner G, Franco-Cereceda A: Ion channels involved in the release of calcitonin generelated peptide by low pH, prostacyclin and capsaicin in the isolated guinea-pig heart. Eur J Pharmacol 1998;in press. V. Källner G, Gonon A, Franco-Cereceda A: Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig. Cardiovasc Res 1998;38:493-499. VI. Källner G, Franco-Cereceda A: Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP). J Cardiovasc Pharmacol , accepted for publication. VII. Källner G, Öwall A, Franco-Cereceda A: Myocardial outflow of calcitonin gene-related peptide in relation to metabolic stress during coronary artery bypass grafting without cardiopulmonary bypass. Submitted for publication.