Antitumour Activity of Bauhinia variegata Against Ehrlich Ascites Carcinoma Induced Mice |
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| Authors: | B Rajkapoor B Jayakar N Murugesh |
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| Institution: | 1. Department of Pharmacology, Vinayaka Mission's College of Pharmacy, Yercaud Road, Salem, 636 008, Tamil Nadu, India;2. Institute of Pharmacology, Madurai Medical College, Madurai, 625 020, Tamil Nadu, India |
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| Abstract: | The antitumour activity of ethanol extract of Bauhinia variegata (EBV) has been evaluated against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. A significant enhancement of mean survival time of EBV treated tumour bearing mice was found with respect to the control group. EBV treatment was found to enhance peritoneal cell counts. After 14 days of inoculation, EBV is able to reverse the changes in the haemotological parameters, protein and PCV consequent to tumour inoculation. Oral administration of EBV was effective in reducing solid tumour mass development induced by EAC cells. EBV was found to be a potent cytotoxic towards EAC tumour cells. |
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| Keywords: | Bauhinia variegata Ehrlich ascites carcinoma heamotological sutides in vitro cytotoxicity life span solid tumour |
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