Anti-inflammatory effect of petroleum ether extract of Vitex negundo leaves in rat models of acute and subacute inflammation |
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Authors: | Jaganathan Subramani A Damodaran M Kanniappan LN Mathuram |
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Institution: | 1. Department of Pharmacology and Toxicology, Madras Veterinary College, Chennai, Indiasubramani.jaganathan@gmail.com;3. Department of Pharmacology and Toxicology, Madras Veterinary College, Chennai, India |
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Abstract: | The anti-inflammatory effect of a petroleum ether extract of Vitex negundo Linn (Verbenaceae) leaves, (PEVNL) (250 and 500?mg/kg, p.o.), was evaluated in carrageenan-induced hind paw edema and cotton pellet granuloma models. Diclofenac sodium was used as a standard drug. The biochemical parameters were estimated in serum. In carrageenan-induced rat paw edema model PEVNL exhibited significant (p?<?0.01) inhibition of edema volume at 4?h in a dose-dependent manner. In the cotton pellet granuloma model, dry weight of cotton pellets was significantly inhibited in a dose-dependent manner with maximum effect noticed at 500?mg/kg, p.o. Both doses of PEVNL were found to normalize the increased alkaline phosphatase, acid phosphatase, alanine amino transferase (ALT) and aspartate amino transferase (AST) and reversed the decreased serum albumin. In conclusion, PEVNL exhibited anti-inflammatory activity in acute and subacute models. At a dose of 500?mg/kg, p.o., PEVNL was found to possess maximum activity, and this effect was comparable with reference drug diclofenac sodium (5?mg/kg, p.o.). |
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Keywords: | Anti-inflammatory carrageenan cotton pellet diclofenac sodium paw edema Vitex negundo |
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