Dietary Administration of Asimina triloba. (Paw Paw) Extract Increases Tumor Latency in N.-Methyl-N.-nitrosourea–Treated Rats |
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| Authors: | Muriel Cuendet Carol P Oteham Richard C Moon William J Keller Paul A Peaden John M Pezzuto |
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| Institution: | 1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, College of Pharmacy, Nursing, and Health Sciences, Purdue University, West Lafayette, Indiana, USA;2. Nature's Sunshine Products, Inc., Spanish Fork, Utah, USA;3. University of Hawaii at Hilo, College of Pharmacy, Hilo, Hawaii, USA |
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| Abstract: | AbstractThe paw paw tree, Asimina triloba. (L.) Dunal (Annonaceae), contains more than 50 bioactive components, primarily annonaceous acetogenins. Some therapeutic activities have been associated with this material, but the potential to mediate a cancer chemopreventive effect has not been reported. In this study, a standardized extract from the twigs, in which bullatacin, asimicin, and trilobacin represent the most potent and major bioactive acetogenins, was tested in the N.-methyl-N.-nitrosourea–induced mammary carcinogenesis model. With Sprague-Dawley rats given a diet containing paw paw extract (1250 and 2500 mg/kg diet; based on maximum tolerated dose studies), mammary tumor latency was increased from 55 to 66 days. However, mammary tumor incidence and multiplicity were not affected by extract consumption. |
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| Keywords: | Acetogenins annonaceous Asimina triloba bullatacin carcinogenesis paw paw tree prevention of mammary |
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