YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease |
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| Authors: | Yongzhong Wang Rasmus Sejersten Ripa Julia Sidenius Johansen Anders Gabrielsen Daniel A. Steinbrüchel Tina Friis |
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| Affiliation: | 1. Medical Department B, Cardiac Catheterization Laboratory, The Heart Centre, Rigshospitalet, University Hospital Copenhagen, Faculty of Health Sciences, University of Copenhagen, Denmark;2. Department of Rheumatology, Herlev Hospital, Univeristy of Copenhagen, Denmark;3. Center for Molecular Medicine, Cardiovascular Research Unit, Karolinska Hospital, Stockholm, Sweden;4. Department of Thoraxic Surgery, the Heart Centre, Rigshospitalet, University Hospital Copenhagen, Denmark |
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| Abstract: | Background. YKL-40 is involved in remodelling and angiogenesis in non-cardiac inflammatory diseases. Aim was to quantitate plasma YKL-40 in patients with ST-elevation myocardial infarction (STEMI) or stable chronic coronary artery disease (CAD), and YKL-40 gene activation in human myocardium. Methods and results. We included 73 patients: I) 20 patients with STEMI; II) 28 patients with stable CAD; III) 15 CAD patients referred for coronary by-pass surgery. YKL-40 mRNA expression was measured in myocardium subtended by stenotic or occluded arteries and areas with no apparent disease; and IV) 10 age-matched healthy controls. Plasma YKL-40 was significantly increased in patients with STEMI (88 µg/l, median) and CAD (66 µg/l) compared to controls (16 µg/l, p<0.01 for both). Plasma YKL-40 correlated with CRP at baseline in STEMI (r=0.53, p=0.02) and CAD patients (r=0.41, p=0.031).YKL-40 gene expression was similar in ischemic and non-ischemic myocardium. Conclusions. Plasma YKL-40 was significantly increased in patients with STEMI and stable CAD. Further studies will define the role of YKL-40 as a clinically useful marker for myocardial ischemia, remodelling and maybe prognosis. |
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| Keywords: | Inflammation STEMI myocardial ischemia YKL-40 CRP gene expression |
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