Isolation of the Lignan 6-Methoxypodophyllotoxin from Linum boissieri. and Biosynthesis of Lignans in this Species |
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| Authors: | Belma Konuklugil Elisabeth Fuss Willi. Alfermann |
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| Affiliation: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, Tando?an, Ankara, Turkey;2. Institut für Entwicklungs- und Molekularbiologie der Pflanzen, Heinrich-Heine-Universit?t Düsseldorf, Düsseldorf, Germany |
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| Abstract: | AbstractWe were able to establish a suspension culture of Linum boissieri. that produces 6-methoxypodophyllotoxin (6MPT). As a first step to gain insight into the lignan biosynthesis in L. boissieri. cell cultures, we were able to measure phenylalanine ammonia-lyase (PAL) activity in raw protein extracts. PAL is a key enzyme in the early part of the general phenylpropanoid pathway, leading (beside others) to the precursors for lignan biosynthesis. |
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| Keywords: | Lignan Linum boissieri 6-methoxypodophyllotoxin |
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