Antihyperlipidemic effect of aqueous extract of Plumbago zeylanica roots in diet-induced hyperlipidemic rat |
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Authors: | Sudha R. Pendurkar |
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Affiliation: | C. U. Shah College of Pharmacy, S. N. D. T. Women’s University, Santacruz (W), Mumbai, India |
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Abstract: | This study examined the antihyperlipidemic effect of the aqueous extract of Plumbago zeylanica Linn. (Plumbaginaceae) roots in diet-induced hyperlipidemic rats. The oral administration of the aqueous extract at the dose of 20, 40, and 80?mg kg?1 were found to ameliorate the hyperlipidemic condition as evidenced by a reduction of cholesterol and triglyceride levels. The standards fenofibrate (20?mg kg?1) and atorvastatin (8?mg kg?1) were also found to exhibit significant (p?0.05) cholesterol and triglyceride lowering effect. Further, the aqueous extract at all doses demonstrated a significant (p?0.05) increase in fecal cholesterol excretion indicating a reduction in intestinal cholesterol absorption. Additionally, the activity of lipogenic enzymes like HMGCoA reductase in the liver remained significantly (p?0.05) low on treatment of aqueous extract (80?mg kg?1), thus decreasing the cholesterogenesis. The aqueous extract (20, 40 and 80?mg kg?1) also significantly (p?0.05) reduced the total lipid content in the liver. Moreover, the aqueous extract demonstrated a potential antioxidant capacity in DPPH and TBARS in vitro antioxidant assay. Thus the results suggest a beneficial role of aqueous extract of Plumbago zeylanica roots in ameliorating the hyperlipidemic condition leading to atherosclerosis. |
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Keywords: | Antihyperlipidemic activity cholesterol fecal cholesterol HMGCoA reductase Plumbago zeylanica triglyceride total lipid |
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