综合评分法优化健骨口服液的澄清工艺

目的优化健骨口服液的除杂澄清工艺。方法应用综合评分法-正交设计优化除杂工艺条件。结果在药液浓度为1∶10,ZTC 1＋1天然澄清剂2组分加入顺序为先B组分后A组分,2组分浓度均为1%,用量分别为每100 ml待处理溶液加入B黏胶液6 ml及A黏胶液3 ml,作用温度为80℃,并搅拌10 min,保温1 h后,固形物去除率为20.03%,淫羊藿苷含量保留率为82.26%。结论 ZTC 1＋1天然澄清剂可以用于健骨口服液的澄清工艺。

Optimization of Clarification Technology for Jiangu Oral Liquid with Multiple Guidelines Grading Method

Objective To of the multiple guidelines grading optimize the clarification technology for Jiangu oral liquid. Methods On the basis method-single factor test, orthogonal design was used to optimize the precipiation process. Results The optimal process was to condense the extract solution to 1：10 （herb： herb solution）. For ZTC 1 ＋ 1 natural clarifier,component B was added before component A. The dosage of clarifier B was 6% in solution twice the amount of the clarifier A. The mixture was stirred for 10 min and kept in water bath for 1 h respectively both at 80 ℃. The solid removal rate was 20.03% and the remaining rate of icariin was 82.26%. Conclusion The ZTC 1 ＋ 1 natural clarifier can be used to effectively remove the impurity in Jiangu oral liquid.