关节腔内注射间充质干细胞治疗半月板损伤的研究进展

背景：半月板损伤治疗效果的欠佳严重影响人们的生活质量，对于运动员而言可能意味着职业生涯的终止。目的：探讨关节腔内注射间充质干细胞治疗半月板缺损的有效性。方法：由第一作者应用计算机检索PubMed、中国期刊全文数据库（CNKI）、维普数据库和万方数据库1980年5月至2012年8月相关文献。在标题、摘要、关键词中以“meniscus, mesenchymal stem cells （MSCs）,intra-articular injection, regeneration”或“半月板，间充质干细胞，关节腔内注射，再生”为检索词进行检索。选择文章内容与关节腔内注射有关者，同一领域文献则选择近期发表在权威杂志文章。初检得到181篇文献，根据纳入标准选择关于半月板损伤的间充质干细胞治疗的62篇文献进行综述。结果与结论：间充质干细胞行关节腔内注射后黏附于半月板损伤部位，并定向分化为半月板纤维软骨细胞，有效促进半月板损伤的修复和半月板的再生。关节腔内注射间充质干细胞治疗半月板损伤具有重要的临床应用价值。

Intra-articular injection of mesenchymal stem cells for treatment of meniscus injury

BACKGROUND： Poor therapeutic effects of meniscus injury greatly influence the quality of life of the patients. What＇s even worse, it may lead to the end of the sport life of athletes. OBJECTIVE： To investigate the efficiency of intra-articular injection of mesenchymal stem ceils in thetreatment of meniscus injury. METHODS： A computer-based online retrieval of PubMed database, CNKI database between May 1980 and August 2012 was performed to search articles regarding intra-articular injection using the key words “meniscus, mesenchymal stem cell, intra-articular injection, regeneration” in English or Chinese. In the same research field, papers published recently or in authoritative journals were selected. A total of 181 papers were initially retrieved. According to inclusion criteria, 62 papers regarding use of mesenchymal stem cells in the treatment for meniscus injuries” were suitable for final analysis. RESULTS AND CONCLUSION： The intra-articulady injected mesenchymal stem cells adhered to the injury site and differentiated into meniscal cells,thus effectively enhanced the repair of meniscus injury and accelerated meniscus regeneration. Intra-articular injection of mesenchymal stem cells is of great clinical value for treatment of meniscus injury.