组织工程化神经导管修复外周神经损伤

背景：神经导管技术理论上采用生物或非生物材料预制成合适的管状支架,桥接神经断端两侧,在提供神经再生微环境的同时通过神经诱导、营养作用促进神经再生.目的：观察组织工程化神经导管修复外周神经损伤的临床效果.方法：选择24例陈旧性上肢神经损伤患者,以患者自愿原则分2组治疗：试验组采用组织工程化神经导管修复,对照组采用自体周围体表感觉神经移植修复.治疗后随访6个月观察患者肢体神经损伤功能修复效果.结果与结论：随访6个月后,两组肢体远端感觉运动功能与目测类比疼痛评分均较治疗前改善（P 〈0.05）,且试验组效果更好（P 〈0.05）;两组损伤侧感觉与运动神经传导速度均较治疗前改善（P 〈0.05）,且两组间差异无显著性意义.说明组织工程化神经导管材料符合神经修复导管支架的要求,临床应用疗效肯定.

Tissue-engineered nerve conduits repair peripheral nerve damage

BACKGROUND： Theoretical y, nerve conduit technology uses the biological or non-biological materials to prefabricate suitable tubular stent to bridge the nerve ends on both sides. And it can promote the nerve regeneration through neural induction and nutrition under the nerve regeneration microenvironment. OBJECTIVE： To observe the clinical effects of tissue-engineered nerve conduits for repairing peripheral nerve damage. METHODS： Twenty-four patients with old upper extremity nerve damage were selected, and divided into two groups for the treatment according to voluntary principle. The patients in the experimental group were repaired with tissue-engineered nerve conduits, and those in the control group were repaired with autologous surrounding surface sensory nerve transplantation. Al the patients were fol owed-up for 6 months after treatment to observe the repairing functional effect of limb nerve damage.RESULTS AND CONCLUSION： After fol owed-up for 6 months, the limb distal sensory motor function and visual analogue scale scores of the limbs in the two groups were improved compared with those before treatment （P 〈0.05）, and the experimental group showed better effects （P 〈 0.05）; the sensory and motor nerve conduction velocity of the damaged side in the two groups were improved compared with those before treatment （P 〈 0.05）, and there was no significant difference between the two groups. It indicates that tissue-engineered nerve conduit materials can meet the requirements of nerve repair conduit stent and the clinical application is effective.