| 脱蛋白骨,骨形态发生蛋白和三种生长因子重组合人工骨成？… |
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| 引用本文： | 倪卫东 安洪. 脱蛋白骨,骨形态发生蛋白和三种生长因子重组合人工骨成？…[J]. 中国修复重建外科杂志, 1999, 13(5): 315-320 |
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| 作者姓名： | 倪卫东 安洪 |
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| 摘 要： |
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| 关 键 词： | 骨移植 脱蛋白骨 骨形态发生蛋白 生长因子 |
Comparative study on osteogenesis of three types growth factors recombination artificial bones] |
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| W D Ni,H An,D M Jiang. Comparative study on osteogenesis of three types growth factors recombination artificial bones][J]. Chinese journal of reparative and reconstructive surgery, 1999, 13(5): 315-320 |
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| Authors: | W D Ni H An D M Jiang |
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| Affiliation: | Department of Orthopedic Surgery, First Affiliated Hospital, Chongqing University of Medical Science, Chongqing, P. R. China 400016. |
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| Abstract: | OBJECTIVE: To compare the osteogenesis of recombination artificial bones, which are bovine deproteined bone (bDPB) and bovine bone morphogenetic protein (bBMP), combined with tumor necrosis factor alpha (TNF alpha), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) respectively. METHODS: One hundred trephined skull bone defects in fifty rabbits were divided into four groups, which implanted with bDPB/bBMP/TNF alpha, bDPB/bBMP/bFGF, bDPB/bBMP/EGF, and bDPB/bBMP respectively. X-ray and histological changes were observed in the 1st, 2nd, 4th, 6th, 8th weeks after implantation. The content of 35S and 45Ca and ash weight were measured at 10 and 42 days after operation. RESULTS: The osteogenesis of bDPB/bBMP/TNF alpha group was stronger than that of bDPB/bBMP/bFGF group(P < 0.01), while bDPB/bBMP/bFGF group was stronger than that of bDPB/bBMP/EGF(P < 0.01). No significant statistical difference were found between bDPB/bBMP/EGF and bDPB/bBMP(P > 0.05). CONCLUSION: TNF alpha combined with bBMP and carrier can stimulate bone formation and increase the volume of new bone in vivo. It suggests that bDPB/bBMP/TNF alpha is a valuable biomaterial of bone graft. |
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