心房颤动患者血浆C反应蛋白浓度的变化研究

目的探讨C反应蛋白(CRP)作为系统因子在心房颤动的发生与维持中的变化及意义。方法用酶联免疫吸附双抗体夹心法(hsCRP ELLSA)对21例孤立性阵发性房颤者(LPAF)分别于房颤发作及终止后1周测定外周静脉血浆CRP浓度,并与28例孤立性持续性房颤(LSAF)、27例风心病二尖瓣狭窄伴持续性房颤(RHD)、32例阵发性室上性心动过速(PSVT)及20例健康对照组相比较。结果LPAF病人房颤发作时及终止后,LSAF和RHD组病人血浆CRP浓度较PSVT及正常对照组明显上升。LPAF病人房颤发作时血浆CRP浓度与房颤发作持续时间呈正相关,与患者年龄、性别及左心房内径无关。而PSVT时血浆CRP浓度与心动过速持续时间无明显相关性。结论炎症反应可能参与孤立性房颤的发生与维持。

Changes of concentration of plasma C-reactive protein in patients with atrial fibrillation

Objective To explore link of change of plasma C-reactive protein (CRP) and atrial fibrillation (AF). Method The hsCRP enzyme-linked immunosorbent assay (ELISA) methods were used to measure plasma CRP levels in 21 patients with lone paroxysmal AF (LPAF) during AF and 7 days after return to sinus rhythm ;28 patients with lone sustained atrial fibrillation(LSAF) and 27 patients with rheumatic heart disease and chronic AF(RHD).Levels of plasma CRP were compared to levels in 32 patients with paroxysmal supraventricular tachycardia(PSVT) and 20 voluntary healthy subjects. Results Patients with LPAF,LPAF and RHD had high levels of CRP when compared with PSVT and the healthy subjects.No significant changes of CRP levels were found between the onset AF patients and those after 7 days of recovery.Patients with lone persistent AF and rheumatic heart disease with persistent AF had higher levels of CRP than those with LPAF,but have no significance.There were positive correlation between the duration of AF and the levels of CRP.But there were no relation with left atrial size on echocardiography,sex and ages. Conclusion These results indicate that elevated CRP levels in AF patients may play an important role in the occurrence and sustainment of AF.