| 缺血性脑血管疾病的遗传模式 |
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| 引用本文： | 喻文雅,刘君卿,李四凯,刘会喜,史春伟,李怡秋,马丽莉,郭玉钗. 缺血性脑血管疾病的遗传模式[J]. 职业与健康, 2010, 26(8): 941-943 |
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| 作者姓名： | 喻文雅 刘君卿 李四凯 刘会喜 史春伟 李怡秋 马丽莉 郭玉钗 |
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| 作者单位： | 河北省石家庄市疾病预防控制中心,050011 |
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| 摘 要： | 目的探讨缺血性脑血管疾病的遗传模式。方法对157个缺血性脑血管家系用分离分析法和多基因阈值理论进行遗传模式的研究。结果缺血性脑血管发病既不符合常染色体显性遗传和隐性遗传模式也不符合性连锁遗传方式,而属于多基因遗传病。结论缺血性脑血管病为多基因遗传疾病,平均遗传度为(75.06±3.23)%,对有遗传易感性人群应重点管理,加强防治。
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| 关 键 词： | 缺血性脑血管疾病 遗传模式 遗传度 |
A Study on the Genetic Model of Ischemic Cerebrovascular Disease |
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| YU Wen-ya,LIU Jun-qing,LISi-kai,LIU Hui-xi,SHIChun-wei,LIYi-qiu MALi-li,GUO Yu-chai. A Study on the Genetic Model of Ischemic Cerebrovascular Disease[J]. Occupation and Health, 2010, 26(8): 941-943 |
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| Authors: | YU Wen-ya LIU Jun-qing LISi-kai LIU Hui-xi SHIChun-wei LIYi-qiu MALi-li GUO Yu-chai |
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| Affiliation: | YU Wen-ya,LIU Jun-qing,LISi-kai,LIU Hui-xi,SHIChun-wei,LIYi-qiu MALi-li,GUO Yu-chai(Shijiazhuang Center for Disease Control , Prevention,Shijiazhuang 050011,China) |
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| Abstract: | [Objective] To investigate the genetic model of ischemic cerebrovascular disease.[Methods]The genetic model of ischemic cerebrovascular disease was analyzed with segregation analysis and multi-gene threshold theory in 157 pedigrees.[Results]The genetic model of ischemic cerebrovascular disease was neither autosomal dominant inheritance and recessive inheritance nor sex-linked inheritance, it was a polygenic disease.[Conclusion]Ischemic cerebrovascular disease was a polygenic disease, and the average heritab... |
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| Keywords: | Ischemic cerebrovascular disease Genetic Model Heritability |
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