Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression |
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| Authors: | Ji-Soo Kim Ah-Yeon Kim Hyeon-Myeong Shin Sang-Il Ahn Hyun-Jin Shim Kung-Woo Nam |
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| Institution: | 1. Department of Medical Science, College of Medical Sciences, Soonchunhyang University, Asan, Republic of Korea;2. Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, Republic of Korea;3. Department of Life Science and Biotechnology, College of Natural Science, Soonchunhyang University, Asan, Republic of Korea |
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| Abstract: | Inflammation is a pathological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies to treat cough, asthma, and insect bites. Here, we investigated the effects of A. yomena extract (EAY) on the expression of COX-2 and iNOS induced by LPS. EAY inhibited NF-κB activation and IκBα degradation induced by LPS. EAY suppressed LPS-induced COX-2 and iNOS expression which are the target genes regulated through NF-κB activation in macrophages. EAY also suppressed LPS-induced nitrite production. These results suggest that EAY has the potential to be developed as a potent anti-inflammatory drug. |
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| Keywords: | Aster yomena inflammation nuclear factor-κB cyclooxygenase-2 inducible nitric oxide synthase |
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