Circulating endothelial progenitor cell levels are higher during childhood than in adult life |
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| Authors: | Jie Kim E Goossens Michèle H J van Oostrom Olivia Lilien Marc R Verhaar Marianne C |
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| Affiliation: | 1. Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK;2. BHF/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK;3. Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK;4. National Heart and Lung Institute, Imperial College London, London, UK;5. Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, New York, New York, USA;6. Research, Development & Innovation, Scottish National Blood Transfusion Service, Ellen''s Glen Road, Edinburgh, UK;1. Department of Biology of Reproduction, Institute of Animal Science, Prague, Czech Republic;2. Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic;3. Department of Molecular Genetics, Institute of Animal Science, Prague, Czech Republic;4. Department of Animal Husbandry, Czech University of Life Sciences, Prague, Czech Republic;1. Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan;2. Department of Primary Care Medicine, College of Medicine (COM), National Taiwan University (NTU), Taipei, Taiwan;3. Department of Obstetrics/Gynecology, National Taiwan University Hospital (NTUH), NTU, Taipei, Taiwan;4. Department of Orthopedic Surgery, NTUH, Taipei, Taiwan;5. Institute of Biomedical Engineering, COM, NTU, Taipei, Taiwan;6. Research Center for Developmental Biology & Regenerative Medicine, NTU, Taipei, Taiwan;1. University of ?ilina, Faculty of Mechanical Engineering, Department of Material Engineering, Univerzitná 8215/1, 010 26 ?ilina, Slovakia;2. University of Parma, Department of Industrial Engineering, Parco Area della Scienze 181/A, 43124 Parma, Italy;3. Institute of Physics of Materials, Academy of Sciences of the Czech Republic, ?i?kova 22, 616 62 Brno, Czech Republic |
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| Abstract: | Age-related vascular dysfunction contributes to the increased cardiovascular risk in elderly. Endothelial progenitor cells (EPC), a hematopoietic stem cell (HSC) subtype, can improve vascular repair. Therefore, it is hypothesized that a decrease in these circulating progenitor cells during aging plays a role in the enhanced cardiovascular risk. Until now, research has focused on EPC and HSC in the aging adult, but no studies have been conducted in children whereas animal studies specifically suggest a benefit of juvenile bone marrow. We investigated CD34(+)/KDR(+) EPC and CD34(+) HSC numbers by flow cytometry in healthy humans aged 1- to 81-years old. An inverse relation with age was observed for EPC counts [r=-0.37, p=0.007] as well as for HSC counts [r=-0.37, p=0.008]. During childhood significantly higher levels of EPC [p<0.0001] and HSC [p=0.001] were found compared to adults. These findings may have great clinical relevance since increasing circulating EPC levels is a promising therapeutic target to enhance the endogenous regenerative capacity. Better insight in the mechanisms underlying the higher EPC levels in children may provide options to increase EPC counts in adults, thereby potentiating endothelial repair mechanisms. |
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