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RhoA protein expression correlates positively with degree of malignancy in astrocytomas
Authors:Yan Benedict  Chour Han Hwan  Peh Bee Keow  Lim Chinghway  Salto-Tellez Manuel
Affiliation:Department of Pathology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Abstract:Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion, has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas.
Keywords:RhoA   Protein expression   Astrocytomas   Malignancy
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