广东省惠州地区流动人口育龄妇女人乳头瘤病毒感染及宫颈病变的流行病学调查

目的了解广东省惠州地区流动人口育龄妇女人乳头瘤病毒(human papillomavirus,HPV)感染、分型及宫颈病变的现况,分析感染、HPV型别与宫颈病变程度的关系。方法对7 796例已婚育龄妇女进行HPV-DNA检测和分型,对HPV阳性者进行宫颈液基薄层细胞学(thinprep cytology test,TCT)检测,对检测结果进行分析。结果 7 796例受检对象中共检出HPV感染568例(7.29%),以HPV16、58、52、18型多见。25岁以下女性HPV感染阳性率最高(15.97%),高于其他年龄组(P0.05)。对568例HPV感染者进行TCT筛查,ASCUS级以上宫颈病变298例(52.46%)。结论广东省惠州地区流动人口育龄妇女HPV感染主要感染类型为HPV16、58、52、18型,感染者年龄以15~24岁人群最高,宫颈病变发生率及病变程度随感染者年龄增加而升高。定期筛查HPV感染,尤其高龄感染者是早期发现宫颈病变和预防宫颈癌的重要手段。

The epidemiological investigation on women of childbearing age with HPV infection and cervical lesions among floating population in Huizhou of Guangdong Province

Objective To investigate the epidemiology about the women of childbearing age with human papillomavirus （HPV） infection and cervical lesions among floating population in Huizhou of Guangdong province. To analyze the relationship between HPV infection, type of HPV and cervical lesions. Methods 7 796 married women were undergone the HPV- DNA test. Thinprep cytology test（TCT） were conducted in HPV positive cases. Results 568 HPV infections were found in 7 796 cases with a infection rate of 7.29%. Among all the types of HPV, type16, 58, 52, 18 were in common. Women less than 25 years old had the highest positive rates of HPV infection （ 15.97% ） with a statistical significant difference （ P 〈 0. 05 ）. In 568 cases with HPV infection, the TCT screening showed that 289 cases were found abnormal above ASCUS（52.46% ）. Conclusions The women of childbearing age with HPV infection among floating population in Huizhou are mainly of type 16, 58, 52, 18 and 15 ~ 24 years old cases. The incidence rate and lesion severity of cervical lesions increased as the age goes up. Regular screening of HPV infection is an important method to discover cervical lesions in early stage and to prevent cervical cancer especially in older infected women.