| 解毒化瘀方含药血清对白血病K562/A02耐药细胞凋亡的影响 |
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| 引用本文： | 邱国俊,何咏梅,马武开,姚血明,李玉莹,黄颖,王莹. 解毒化瘀方含药血清对白血病K562/A02耐药细胞凋亡的影响[J]. 中国医院药学杂志, 2012, 0(20): 1600-1603 |
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| 作者姓名： | 邱国俊 何咏梅 马武开 姚血明 李玉莹 黄颖 王莹 |
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| 作者单位： | 黔西南州中医院;贵阳中医学院第二附属医院 |
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| 基金项目： | 国家自然基金资助课题(编号:30860353);黔西南州科技计划项目(编号:2009-30) |
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| 摘 要： | 目的:探讨解毒化瘀药含药血清对白血病K562/A02耐药细胞凋亡的影响。方法:应用MTT法检测解毒化瘀药含药血清对K562/A02耐药细胞的生长抑制率,流式细胞仪检测解毒化瘀药含药血清处理后的各组K562/A02细胞凋亡的情况。结果:MTT细胞毒结果显示解毒化瘀药血清能够抑制K562/A02的生长,其抑制率随药物浓度增加而增加,流式细胞检测结果显示解毒化瘀药能促进白血病耐药细胞K562/A02凋亡率,并呈浓度相关性。结论:解毒化瘀药含药血清能够促进K562/A02细胞凋亡。
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| 关 键 词： | 白血病 K562/A02细胞 细胞凋亡 解毒化瘀药 |
Study on the effects of Jiedu Huayu herbs containing serum on apoptosis of leukemia K562/A02 multi-drug resistance cells |
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| QIU Guo-jun,HE Yong-mei,MA Wu-kai,YAO Xue-ming,LI Yu-ying,HUANG Ying,WANG Ying. Study on the effects of Jiedu Huayu herbs containing serum on apoptosis of leukemia K562/A02 multi-drug resistance cells[J]. Chinese Journal of Hospital Pharmacy, 2012, 0(20): 1600-1603 |
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| Authors: | QIU Guo-jun HE Yong-mei MA Wu-kai YAO Xue-ming LI Yu-ying HUANG Ying WANG Ying |
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| Affiliation: | 1.Qian western-southern State Traditional Chinese Medical Hospital,Guizhou Xingyi 562400,China;2.The second affiliated hospital of Guiyang College of Traditional Chinese Medicine,Guizhou Guiyang 550003,China) |
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