肝纤维化诊断及治疗共识（2019年）

肝纤维化是肝脏受到各种损伤后细胞外基质（即胶原、糖蛋白和蛋白多糖等）弥漫性过度沉积与异常分布的修复反应,是各种慢性肝病向肝硬化发展过程中的关键步骤。近年来对肝纤维化基础和临床研究及其认识方面有不少进展,我们为此组织了国内本领域相关专家,就肝纤维化诊断和评估、肝纤维化治疗及肝纤维化治疗药物临床开发应用形成共识,以便更好地指导肝纤维化诊断和治疗及药物研发。

Consensus on the diagnosis and therapy of hepatic fibrosis

Hepatic fibrosis is a repair reaction of diffuse excessive deposition and abnormal distribution of extracellular matrix (collagen, glycoprotein, proteoglycan, etc.) after various liver injuries. It is a key step in the development of various chronic liver diseases to cirrhosis. In recent years, there have been many advances in the basic and clinical aspects of liver fibrosis and its understanding. For this reason, we have organized domestic experts in this field to form consensus on the diagnosis and evaluation of liver fibrosis, the treatment of liver fibrosis and the clinical development and application of drugs for the treatment of liver fibrosis, so as to better guide the diagnosis and treatment of liver fibrosis and drug research and development.