Dipropylene Glycol Monomethyl Ether: A 13-Week Inhalation Toxicity Study in Rats and Rabbits

Dipropylene Glycol Monomethyl Ether. A 13-Week Inhalation Studyin Rats and Rabbits. LANDRY, T. D., AND YANO, B. L. (1984).Fundam. Appl. Toxicol. 4, 612–617. Fischer 344 rats (10/sex/exposureconcentration) and New Zealand White rabbits (7/sex/exposureconcentration) were exposed to 0, 15, 50, or 200 ppm (0, 91,303, or 1212 mg/m3) of dipropylene glycol monomethyl ether (DPGME)for 6 hr/day, 5 days/week for 13 weeks. Criteria of responseincluded general observations, body weights, clinical chemistry,hematology, urinalyses (rats only), necropsy, organ weights,and histopathology. There were no effects attributed to exposureto DPGME at any exposure concentration in either male or femalerats or rabbits. The highest concentration tested (200 ppm)was approximately 40% of a saturated DPGME atmosphere. Basedon the low vapor pressure of DPGME, and results in this 13-weekstudy, DPGME appears to have a low subchronic vapor inhalationtoxicity hazard.