Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats |
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| Authors: | S S Chauhan S K Singh U K Misra |
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| Institution: | Department of Biochemistry, V.P. Chest Institute, University of Delhi, India. |
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| Abstract: | The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility. |
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