| 吡罗昔康多晶型的制备及其热稳定性 |
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| 引用本文： | 赵会英,苏德森,胡愈,黄永玲. 吡罗昔康多晶型的制备及其热稳定性[J]. 沈阳药科大学学报, 2000, 17(2): 101-102,113 |
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| 作者姓名： | 赵会英 苏德森 胡愈 黄永玲 |
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| 作者单位： | 1. 沈阳药科大学药学系
2. 辽宁省医药工业研究院,沈阳,110015 |
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| 基金项目： | 辽宁省自然科学基金资助项目!No96 2 2 19 |
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| 摘 要： | 在不同条件下对吡罗昔康进行了重结晶 ,经熔点测定、红外光谱、差热分析和粉末X 射线衍射法鉴定 ,确认吡罗昔康至少存在A、B两种晶型和一个水加合物C .采用差热分析法对A、B和C的热稳定性进行了比较 ,给出热分解活化能 .
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| 关 键 词： | 吡罗昔康 多晶型 稳定性 活化能 |
Preparation and Heat Stability of Piroxicam Polymorphs |
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| Zhao Huiying,Su Desen,Hu Yu,Huang Yongling. Preparation and Heat Stability of Piroxicam Polymorphs[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(2): 101-102,113 |
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| Authors: | Zhao Huiying Su Desen Hu Yu Huang Yongling |
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| Abstract: | The raw drug of piroxicam has been recrystalized from several solvents. The results of the melting points,DTA,IR and powder X-ray diffraction analysis confirmed that simple crystalization from different solvents yielded only two crystal forms (A and B) and one hydrate(C).The solid stability of A, B and C were studied with DTA,and the heat degradation activation energy of each form was calculated. |
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| Keywords: | piroxicam polymorphism stability activation energy |
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