平阳霉素白蛋白微球栓塞动脉和体内降解的动态观察

目的 研究平阳霉素白蛋白微球(PYM-AMS)诱导小动脉栓塞的作用和体内降解的过程.方法 选择健康成年日本大耳白兔24只,采用区组随机法,在每只兔双耳的中央动脉分别注射入PYM水剂、PYM油剂、PYM-AMS油剂各0.26 mL,PYM浓度为5 mg/mL.分别于注射后第2 d、7 d、14 d、21 d处死动物,动态观察注射药物后的动静脉改变和PYM-AMS的形态变化.结果 PYM水剂组,血管壁和血管内皮细胞无明显改变;PYM油剂组,约14 d时,出现血管充盈略下降,21 d有血管内膜及血管内皮细胞增生;PYM-AMS油剂组,7 d后血管出现缩窄,远心端有小血栓,血管逐渐机化,约21 d时,血管闭锁,血流中断.微球在注射后14 d,有吸收改变,逐渐有炎细胞浸润、组织侵入而降解.结论 PYM-AMS通过栓塞和缓释PYM的作用,诱导小动脉闭锁,在体内2周后出现降解,未引起剧烈的炎性反应.PYM-AMS可作为动静脉血管畸形治疗或恶性肿瘤的局部化学治疗的选择性药物参考.

Embolization and Degradation of Arteries in vivo by Pingyangmycin Albumin Microspheres

Objective To investigate the embolization effect of Pingyangmycin-albumin microspheres(PYM-AMS) on small arteries and its process of degradation in vivo.Methods Twenty four Japanese white rabbits were randomly divided into four groups,6 in each group.PYM hydrochloride + 0.9% NaCl,PYM + soybean oil,and PYM-AMS + soybean oil were injected into the central auricular arteries of the rabbits in the three experimental groups,respectively,for about 30 seconds(0.26 mL/per ear,which contained PYM 5 mg/mL).The vessel...