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| 山茱萸总甙滴眼液防治角膜移植免疫排斥反应的实验研究 | |
| 引用本文： | 孟晶,陈建苏,李辰,赵松滨,杨皓庄,张穗梅,狄静芳.山茱萸总甙滴眼液防治角膜移植免疫排斥反应的实验研究[J].中国病理生理杂志,2003,19(4):511-513. |
| 作者姓名： | 孟晶 陈建苏 李辰 赵松滨 杨皓庄 张穗梅 狄静芳 |
| 作者单位： | 1. 暨南大学医学院眼科, 广东 广州 510632; 2. 暨南大学病理生理学教研室, 广东 广州 510632; 3. 暨南大学组织移植与免疫中心, 广东 广州 510632 |
| 基金项目： | 广东省卫生厅医学科学技术研究基金资助项目 (A2 0 0 2 32 2 )，广东省中医药管理局科研课题 ( 30 2 0 0 4) |
| 摘 要： | 目的:观察山茱萸总甙(COG)滴眼液局部应用对角膜移植免疫排斥反应的影响。方法:建立封闭群大鼠角膜移植模型,用裂隙灯显微镜记录及比较各组角膜排斥反应发生时间;并进行病理学和扫描电镜检查。结果:病理学检查B、C组15d时的角膜植片淋巴细胞浸润及新生血管明显少于A组。免疫组化显示:ICAM-1的表达在15d时B、C组明显少于A组。结论:COG滴眼液能有效地防治角膜移植免疫排斥反应。 |
| 关 键 词： | 山茱萸 眼药水 角膜移植 免疫排斥 |
| 文章编号： | 1000-4718(2003)04-0511-03 |
| 收稿时间： | 2002-05-20 |
Effect of cornus officinalis glycosides ophthalmic solution on the corneal allograft rejection |
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| MENG Jing,CHEN Jian-su,LI Chen,ZHAO Song-bin,YANG Hao-zhuang,ZHANG Sui-mei,DI Jing-fang.Effect of cornus officinalis glycosides ophthalmic solution on the corneal allograft rejection[J].Chinese Journal of Pathophysiology,2003,19(4):511-513. | |
| Authors: | MENG Jing CHEN Jian-su LI Chen ZHAO Song-bin YANG Hao-zhuang ZHANG Sui-mei DI Jing-fang |
| Institution: | 1. Department of Ophthalmology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China; 2. Department of Pathophysiology, Medical College, Jinan University, Guangzhou 510632, China; 3. Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China |
| Abstract: | AIM: To observe the effect of cornus of ficinalis glycosides(COG) ophthalmic solution on the corneal allograft rejection by topical instillation. METHODS: The corneal transplantation model on the closed colony rats was established. The rejection time of all animals was recorded and compared by slit-lamp microscope. The pathologic changes were measured by immunohistochemistry and scanning electron microscope.RESULTS: The histopathological and immunohistochemistry findings showed that the lymphocytes, neovascularity and the expression of ICAM-1 in COG-treated group were significantly fewer than that in control group at 15 d after operation.CONCLUSION: COG ophthalmic solution prevents and suppresses the corneal allograft rejection. |
| Keywords: | Fructurs corni Ophthalmic solutions Corneal transplantation Immunologic rejection |
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