Factors related to diagnostic sensitivity using an ultrathin bronchoscope under CT guidance |
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Authors: | Shinagawa Naofumi Yamazaki Koichi Onodera Yuya Asahina Hajime Kikuchi Eiki Asano Fumihiro Miyasaka Kazuo Nishimura Masaharu |
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Affiliation: | First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kitaku, Sapporo 060-8638, Japan. |
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Abstract: | BACKGROUND: We investigated factors related to the diagnostic sensitivity of CT-guided transbronchial biopsy (TBB) using an ultrathin bronchoscope and virtual bronchoscopy (VB) navigation for small peripheral pulmonary lesions. METHOD: We have performed this procedure on 83 patients with 85 small peripheral pulmonary lesions (< 20 mm in diameter). We analyzed the relationship between the diagnostic sensitivity and the location of the lesions, the bronchial generation to which an ultrathin bronchoscope was inserted, and the lesion-bronchial and lesion-pulmonary arterial relationships on high-resolution CT. RESULTS: Fifty-six of the 85 lesions (66%) were diagnosed following CT-guided TBB using an ultrathin bronchoscope with VB navigation. The lesions located in the left superior segment of the lower lobe (S6) had a significantly low diagnostic sensitivity compared to other locations (p < 0.01). When an ultrathin bronchoscope could be inserted to the fifth or greater bronchial generation, the yield was above the average diagnostic sensitivity of 66%. Moreover, not only the patients with the presence of a bronchus leading directly to a lesion (CT-bronchus sign), but also the patients with the presence of a pulmonary artery leading to a lesion (CT-artery sign), had high diagnostic sensitivity (p < 0.01). Multivariate analysis revealed that the location of lesion was an independent predictor of diagnostic sensitivity (p < 0.05). CONCLUSIONS: The location of the lesion, the bronchial generation to which an ultrathin bronchoscope was inserted, and the presence of a bronchus as well as a pulmonary artery leading to the lesion were valuable for predicting successful CT-guided TBB using an ultrathin bronchoscope with VB navigation. |
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Keywords: | CT artery sign CT-guided transbronchial biopsy small peripheral pulmonary lesion ultrathin bronchoscope virtual bronchoscopic navigation FB" },{" #name" :" keyword" ," $" :{" id" :" cekeyw70" }," $$" :[{" #name" :" text" ," _" :" flexible bronchoscopy HRCT" },{" #name" :" keyword" ," $" :{" id" :" cekeyw90" }," $$" :[{" #name" :" text" ," _" :" high-resolution CT TBB" },{" #name" :" keyword" ," $" :{" id" :" cekeyw110" }," $$" :[{" #name" :" text" ," _" :" transbronchial biopsy VB" },{" #name" :" keyword" ," $" :{" id" :" cekeyw130" }," $$" :[{" #name" :" text" ," _" :" virtual bronchoscopy |
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