| 萸冰制剂对实验性偏头痛大鼠血清NO/NOS含量的影响 |
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| 引用本文： | 逯振宇,邱德文,许建阳,蔺兴遥.萸冰制剂对实验性偏头痛大鼠血清NO/NOS含量的影响[J].辽宁中医学院学报,2011(1):195-197. |
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| 作者姓名： | 逯振宇 邱德文 许建阳 蔺兴遥 |
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| 作者单位： | [1]浙江佐力药业有限公司,浙江德清510282 [2]贵阳中医学院,贵州贵阳550002 [3]武警总医院,北京100039 [4]甘肃中医学院,甘肃兰州730000 |
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| 摘 要： | 萸冰制剂是由华佗再造丸中主药吴茱萸与冰片组成。根据硝酸甘油、NO/NOS、偏头痛的内在联系,文章利用硝酸甘油型实验性偏头痛动物模型,并用硝酸还原酶法测定其血液中的NO/NOS含量。结果表明：硝酸甘油实验性偏头痛大鼠血清中NO/NOS的含量明显增强,萸冰制剂能明显降低偏头痛大鼠血清中NO/NOS的含量,且降低NO/NOS含量的作用明显优于西药阳性组（麦角胺咖啡因）和中药阳性组（正天丸）,与模型组比较有显著或极显著差异。提示：萸冰制剂具有治疗实验性偏头痛动物模型的作用。
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| 关 键 词： | 吴茱萸 冰片 一氧化氮 一氧化氮合酶 硝酸甘油 偏头痛 |
Effects on NO/NOS Content in Migraine Rat Serum Models |
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| LU Zhen-yu,QIU De-wen,XU Jian-yan,LIN Xing-yao.Effects on NO/NOS Content in Migraine Rat Serum Models[J].Journal of Liaoning College of Traditional Chinese Medicine,2011(1):195-197. |
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| Authors: | LU Zhen-yu QIU De-wen XU Jian-yan LIN Xing-yao |
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| Institution: | 1.Zhejiang Jolly Pharmaceutical Co.,Ltd,Deqing 323100,Zhejiang,China;2.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,Guizhou,China;3.Armed Police General Hospital,Beijing 100039,China;4.Gansu College of Traditional Chinese Medicine,Lanhou 730000,Gansu,China) |
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| Abstract: | The Yubing-zhiji is made up by euodia ruticarpa and borneolum.According to borneolum,NO,NOS and migraine have inner link.This article uses the borneolum experimental migraine animal model,And determines the NO/NOS content in its blood with the nitric acid reductases method.The result indicated：In glonoine experimental migraine rat serum NO/NOS content obvious enhancement.The Yubing-zhiji can reduce migraine rat serum the NO/NOS content in obviously.Also reduces the NO/NOS content the function to surpass the western medicine group obviously（ergotamine caffeine）and the Chinese medicine group（Zhentian pill）.Has difference extremely with the model group comparison.Prompt：The Yubing-zhiji has the treatment experimental migraine animal model function. |
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| Keywords: | Euodia ruticarpa Borneolum NO NOS migraine glonoin |
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