| 血管内皮细胞凋亡研究进展 |
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| 引用本文： | 王书乐,张志斌. 血管内皮细胞凋亡研究进展[J]. 辽宁中医学院学报, 2011, 0(3): 50-53 |
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| 作者姓名： | 王书乐 张志斌 |
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| 作者单位： | 江苏省无锡市中医医院中心实验室,江苏无锡214001 |
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| 基金项目： | 基金项目：江苏省中医药科技项目（LZ09099） |
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| 摘 要： | 凋亡诱导剂通过Fas/FasL/caspase途径、Cyt C途径、TNF-α途径及PARP途径等诱导血管内皮细胞凋亡。抗凋亡诱导剂通过干扰细胞凋亡的信号通路来抑制凋亡。中药作为广泛使用的抗凋亡药物在临床上已取得显著成效,但其部分具体的分子机制还不清楚。文章对血管内皮细胞凋亡的4条信号通路及凋亡诱导剂和抗凋亡诱导剂的研究进展作一综述。
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| 关 键 词： | 血管内皮细胞 凋亡 |
Apoptosis of Vascular Endothelial Cells |
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| WANG Shu-le,ZHANG Zhi-bin. Apoptosis of Vascular Endothelial Cells[J]. Journal of Liaoning College of Traditional Chinese Medicine, 2011, 0(3): 50-53 |
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| Authors: | WANG Shu-le ZHANG Zhi-bin |
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| Affiliation: | (Central Laboratory,Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Wuxi 214001,Jiangsu,China) |
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| Abstract: | Vascular endothelial cells receive multiple information from their environment that eventually leads them to apoptosis.The spotlight is now on four main signal transduction pathways：the Fas/FasL/caspase pathway,the Cyt C pathway,the TNF-α signaling system and the PARP pathway.We aim to review herein the main pathways mentioned above as well as the pro-or anti-apoptosis reagents which regulate the apoptosis or anti-apoptosis through triggering or interference with these signaling mechanisms.Further work is required to better elucidate the detail molecular mechanism of Chinese medicine which is widely used in the anti-apoptosis effect in human vascular endothelial cells. |
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| Keywords: | vascular endothelial cell apoptosis |
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