| 炮制对何首乌小鼠急性毒性的影响 |
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| 引用本文： | 李玥,徐立,刘若囡,陈诚,时乐.炮制对何首乌小鼠急性毒性的影响[J].辽宁中医学院学报,2011(5):248-249. |
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| 作者姓名： | 李玥 徐立 刘若囡 陈诚 时乐 |
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| 作者单位： | 南京中医药大学,江苏南京210046 |
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| 基金项目： | 南京中医药大学青年自然科学基金资助项目（09XZR22） |
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| 摘 要： | 目的：生、制首乌水提液、醇提液对小鼠的急性毒性考察。方法：采用LD50、MLD急性毒性实验方法分别测定生、制首乌水提液、醇提液口服最大给药量、半数致死量。结果：生首乌醇提物的LD50为287.87g.kg-1,制首乌醇提物的606.88g.kg-1。生首乌水提物最大给药量为184g.kg-1,制首乌水提物最大给药量为264g.kg-1。结论：何首乌炮制前后的醇提液对小鼠均有一定的毒性,其中生首乌醇提液急性毒性大于制首乌醇提液。
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| 关 键 词： | 生首乌 制首乌 小鼠 急性毒性 |
Acute Toxicity of Polygonum Multiflorum Thunb and Refined in Mice |
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| LI Yue,XU Li,LIU Ruo-nan,CHEN Cheng,SHI Le.Acute Toxicity of Polygonum Multiflorum Thunb and Refined in Mice[J].Journal of Liaoning College of Traditional Chinese Medicine,2011(5):248-249. |
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| Authors: | LI Yue XU Li LIU Ruo-nan CHEN Cheng SHI Le |
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| Institution: | (Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China) |
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| Abstract: | Objective：To study the acute toxicity of different components of Polygonum multiflorum Thumb and Refined,the acute toxic study on water extract and alcohol extract of Polygonum multiflo-rum Thunb and Refined to mice were developed in this paper.Methods：Ig water extract and alcohol extract of Polygonum multiflo-rum Thunb and Refined to mice,the MLD,LD50 were tested differently by the classic methods of acute toxicity.Result：The results showed that the LD50 of alcohol extract of Polygonum multiflo-rum Thunb is 287.87g·kg-1,the LD50 of alcohol extract of Refined is 606.88g·kg-1;the MLD of water extract of Polygonum multiflo-rum Thunb is 184g·kg-1;the MLD of water extract of Refined is 264g·kg-1.Conclusion：We can draw a conclusion from the results that the size order of acute toxicity of Polygonum multiflo-rum Thunb and Refined is alcohol extract of Polygonum multiflo-rum Thunbalcohol extract of Refined. |
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| Keywords: | polygonum multiflo-rum thunb polygonum multiflo-rum thunb refined mice acute toxicity |
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