重组人骨形成蛋白－2与异种骨复合移植的扫描电镜观察

目的：明确含有重组人骨形成蛋白－２（ｒｈＢＭＰ－２）的新型复合异种骨的骨修复能力。方法：将ｒｈＢＭＰ－２与经综合化学处理的新生小羊骨松质（ＣＢ）结合，制备成复合异种骨．将复合异种骨植人兔下颌骨缺损，并以单纯松质骨移植、自体骨移植作为对照组，术后２、４、８、１２周分别取材做扫描电镜观察。结果：复合异种骨移植后，植骨区有大量新骨形成，新骨的量随移植时间延长而逐渐增多。自体骨移植组扫描电镜下表现与复合异种骨组基本相同。而单纯骨松质载体移植后，植入区多为纤维结缔组织，新骨形成少．结论：ｒｈＢＭＰ－２可显著促进复合异种骨内的新骨形成。这种新型复合异种骨可能是一种较理想的植骨材料，可望用于人体植骨

Scanning electronic microscope examination of the treated cancellous bone combined with recombinant human bone morphogenetic protein 2 implanted on bone defect

Objective: To determine the ability of a new type of composited xenogeneic bone to repair the bone defect.Methods: The new type of composited xenogeneic bone was obtained by combining the treated cancellous bone with recombinant human bone morphogenetic protein 2(rhBMP 2) and was implanted on the bone defect of rabbit. Results: There were a large amount of new bone formation within the combined material and the amount was increasing as the time lapsed. In contrast, there were a lot of fibrous tissues with a little new bone formed on the area of the bone defect when the treated cancellous bone was implanted alone. Conclusion: The results imply that the rhBMP 2 plays a very important role in new bone formation and the composited xenogeneic bone appear to be an ideal material for the repairment of bone defect.