| HL-329抑制大鼠硬脑膜内神经原性血浆蛋白渗出 |
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| 引用本文： | 李树壮,姜艳华,马丽旭,王怀良,章新华. HL-329抑制大鼠硬脑膜内神经原性血浆蛋白渗出[J]. 临床军医杂志, 1998, 0(3) |
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| 作者姓名： | 李树壮 姜艳华 马丽旭 王怀良 章新华 |
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| 作者单位： | 大连市解放军大连医高专，沈阳市中国医科大学 |
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| 摘 要： | 电刺激三叉神经节或静脉注射辣椒素造成大鼠硬脑膜内血浆蛋白渗出，取下双侧硬脑膜称重并测量其放射性。分别于刺激前４０ｍｉｎ腹腔注射ＨＬ－３２９１０、２０、４０ｍｇ／ｋｇ或相同容量溶剂，观察它们的作用。结果显示电刺激增加了刺激侧硬脑膜内血浆蛋白渗出〔（２１．５０±１．４５）～（３７．８５±３．１９）ｃｐｍ／ｍｇ，Ｐ＜０．０１〕，刺激侧与非刺激侧的比值为１．７６±０．１０。ＨＬ－３２９１０，２０，４０ｍｇ／ｋｇ分别减少其比值到１．５３±０．１４（Ｐ＜０．０５），１．４３±０．０３（Ｐ＜０．０１），１．２０±０．１５（Ｐ＜０．０１）。ＨＬ－３２９明显减少了电刺激和辣椒素造成的大鼠硬脑膜内血浆蛋白渗出。证明ＨＬ－３２９是一潜在的抗偏头痛药物
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| 关 键 词： | HL－329；神经原性炎症；血浆蛋白渗出；硬脑膜 |
HL-329 Blocks Neurogenic Plasma Extravasation in Rat Dura Mater |
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| Abstract: | Electrical unilateral trigeminal ganglion stimulation was performed on male Wistar rats (230 280 g).HL 329 10, 20, 40 mg/kg or tis vehicle were administered (ip) 40 min before stimulation.Both sides of dura mater were dissected and plasma protein leakage were examed by radioactivity measurement (c.p.m/mg wt).The results showed that Electrical trigeminal stimulation increased the leakage of 125I albumin within rat dura mater ratio=176±010 (from 2150±145 to 3785±319 cpm/mg, P<001).HL 329 (at the dose of 10, 20, 40 mg/kg) decreased the ratio from 176±010 to 153±014 (P<005), 143±003 (P<001), 120±015 (P<001) respectively.HL 329 significantly reduced plasma protein extravasation following electrical stimulation in the trigeminal ganglion in the rat ipsilateral dura mater.This might be of clinical importance for the treatmena of acute vascular headaches. |
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| Keywords: | ? HL 329 Neurogenic inflammation plasma protein extravasation dura mater |
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