| 高效液相色谱法同时测定氨咖黄敏胶囊中对乙酰氨基酚和咖啡因的含量 |
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| 引用本文： | 盖轲,郑阿利.高效液相色谱法同时测定氨咖黄敏胶囊中对乙酰氨基酚和咖啡因的含量[J].中国药房,2006,17(6):456-457. |
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| 作者姓名： | 盖轲 郑阿利 |
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| 作者单位： | 1. 甘肃庆阳市陇东学院化学系,庆阳市,745000
2. 甘肃庆阳市药品检验所,庆阳市,745000 |
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| 摘 要： | 目的:建立以高效液相色谱法同时测定氨咖黄敏胶囊中对乙酰氨基酚和咖啡因含量的方法。方法:色谱柱phenomenexlunaC18,流动相为甲醇-水(24∶76),流速为1.0ml/min,柱温为室温,检测波长为215nm,灵敏度为0.01AUFS。结果:对乙酰氨基酚、咖啡因检测浓度分别在50～250μg/ml(r=0.9999)、5.0～25μg/ml(r=0.9999)范围内线性关系良好,平均加样回收率分别为100.7%(RSD=1.8%)、101.4%(RSD=1.4%)。结论:本方法简便、快速、准确,可取代滴定法测定本品含量。
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| 关 键 词： | 高效液相色谱法 氨咖黄敏胶囊 对乙酰氨基酚 咖啡因 含量测定 |
| 文章编号： | 1001-0408(2006)06-0456-02 |
| 收稿时间： | 04 15 2005 12:00AM |
| 修稿时间： | 07 27 2005 12:00AM |
Simutaneous Assaying of Paracetamol and Caffeine in Ankahuangmin Capsules by HPLC |
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| GAI Ke,ZHENG Ali.Simutaneous Assaying of Paracetamol and Caffeine in Ankahuangmin Capsules by HPLC[J].China Pharmacy,2006,17(6):456-457. |
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| Authors: | GAI Ke ZHENG Ali |
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| Institution: | 1.Dept.of Chemistry,Gansu Qingyang Longdong College, Qingyang 745000,China;2.Gansu Qingyang Institute for Drug Control,Qingyang 745000,China |
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| Abstract: | OBJECTIVE:To establish HPLC method for the simultaneous assaying of paracetamol and caffeine in ankahua_ngmin capsules.METHODS:The determination was performed on phenomenex luna C18 column under room temperature;the mobile phase consisted of methanol-water(24∶76) with a flow rate at 1.0ml/min,detecting wavelength at 215 nm and sensibility at 0.01AUFS.RESULTS:The linear ranges for paracetamol and caffeine were 50～250μg/ml(r=0.9 999) and 5.0～25μg/ml(r=0.9 999),respectively.The average recoveries were 100.7%(RSD=1.8%)and 101.4%(RSD=1.4%),respectively.CONCLUSION:This method is simple,rapid and accurate,which can substitute for titration in the assaying of ankahua_ngmin capsules. |
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| Keywords: | HPLC Ankahuangmin capsules Paracetamol Caffeine Assaying |
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