盐酸多奈哌齐治疗血管性痴呆的系统评价

目的 评价盐酸多奈哌齐治疗血管性痴呆（VD）的临床效果和安全性。方法 应用Meta分析方法对11项研究盐酸多奈哌齐治疗VD的自身前后对照试验进行再分析，评价其综合显著性差异和效应大小。结果 ①盐酸多奈哌齐治疗前后的MMSE评分比较：综合检验Z=14．68，自由度22，P〈0．0005；ES：d=1．097。②盐酸多奈哌齐治疗前后的ADL评分比较：综合检验Z=8．30，自由度16，P〈0．0005；ES：d=0．71。③11项研究中报道的药物不良反应的发生率为0．29％-7．1％．主要为胆碱能兴奋的表现。结论 盐酸多奈哌齐是一种治疗VD安全、有效的药物。

Donepezil hydrochloride in the treatment of vascular dementia: a meta-analysis

Objective To assess the effectiveness and safety of donepezil hydrochloride in the treatment of vascular dementia (VD). Methods 11 oneself-controlled trials of donepezil hydrochloride in the treatment of VD were analyzed by meta-analysis in comprehensive test and effect size. Results (1)The significant difference in the scores of Mini-Mental State Examination(MMSE) before and after treatment by donepezil hydrochloride was found, Z=14.68, P<0.0005; ES(effect size)=1.097. (2) The significant difference in the scores of activities of daily living(ADL) before and after treatment by donepezil hydrochloride was found, Z=8.30, P<0.0005; ES=0.714. (3) In 11 studies, the incidence of side reaction was between 0.29% and 7.1%, which mainly was acetycholine excitation symptoms. Conclusion donepezil hydrochloride is an effective and safe agent for treatment of VD