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| 离体人乳腺上皮细胞致癌过程中c-myc肿瘤基因的变化 | |
| 引用本文： | 丁萍,冯永滨,梁燕,柴雨力.离体人乳腺上皮细胞致癌过程中c-myc肿瘤基因的变化[J].第四军医大学学报,1999,20(11):S090-S092. |
| 作者姓名： | 丁萍 冯永滨 梁燕 柴雨力 |
| 作者单位： | 1. 乌鲁木齐军医学院生物化学教研室,新疆,呼图壁,831200 2. 乌鲁木齐职工医科大学 3. 新疆昌吉卫生学校病理学教研室 |
| 摘 要： | 目的：探讨ｃ－ｍｙｃ基因在乳腺癌早期发生过程中的活动状态。方法：利用株人朱上皮细胞ＭＣＦ－１０Ｆ，经３种化学致癌物；ｂｅｎｚｏ（ａ）ｙｒｅｎｅ（ＢＰ），ｄｉｍｅｈｔｈｙｌｂｅｎｚ（ａ）ａｎｔｈｒａｃｅｎｅ（ＤＭＢＡ）和Ｎ－ｍｅｔｈｙｌ－Ｎ－ｎｉｔｒｏｓｏｇｕａｎｉｄｉｎｅ，（ＭＮＮＧ）处理并建立了肿瘤性转化克隆细胞素。其中ＢＰ，ＢＰ１，ＢＰ１－Ｅ来自ＰＢ，ＤＭＢＡ，Ｄ３，Ｄ３－１来自ＭＮＮＧ处理的 |
| 关 键 词： | 乳腺上皮细胞株 化学致癌 c-myc肿癌基因 |
| 文章编号： | 1000-2790(1999)011-S90-S92 |
| 修稿时间： | :1999-06-2 |
Alteration of c-myc oncogene in the human breast epithelial cell line treated by chemical carcinogens in vitro |
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| DING Ping,FENG Yong-Bing,LIANG Yan,CHAI Yu-Li.Alteration of c-myc oncogene in the human breast epithelial cell line treated by chemical carcinogens in vitro[J].Journal of the Fourth Military Medical University,1999,20(11):S090-S092. | |
| Authors: | DING Ping FENG Yong-Bing LIANG Yan CHAI Yu-Li |
| Abstract: | AIM:To study the active status of c myc oncogene in primary breast cancer. METHODS:The human breast epithelial cells (MCF 10f) were treated with benzo(a) pyrene(Bp),dimehthylbenz(a) anthracene(DMBA),and N methyl N nitrosoguanidine (MNNG) respectively, to establish transforming cloned cell line,among them Bp,Bp1,Bp1 E were obtained from Bp treated cell,DMBA,D3,D3 1 from DMBA treated cell,MNNG,M4, from MNNG treated cell. Southern |
| Keywords: | human breast epithelial cell line chemicalcarcinogens c myc oncogene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |