| HPLC法测定熊果酸自微乳中熊果酸的含量 |
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| 引用本文： | 钦富华,林杭娟,高建青. HPLC法测定熊果酸自微乳中熊果酸的含量[J]. 安徽医药, 2012, 0(9): 1257-1258 |
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| 作者姓名： | 钦富华 林杭娟 高建青 |
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| 作者单位： | 1. 浙江医药高等专科学校,浙江 宁波 315100
2. 浙江大学药学院,浙江 杭州 310058 |
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| 摘 要： | 目的建立 HPLC法测定熊果酸自微乳制剂的含量.方法采用 AgilentTC C18色谱柱(250mm×4.6mm,5μm),乙腈 0.3%磷酸(85∶15)为流动相,流速1.0ml·min-1,检测波长210nm,柱温30℃.结果熊果酸在40~160mg·L-1范围内与峰面积呈良好的线性关系(r=0.9999),方法精密度和回收率均符合要求.结论该方法结果准确,重现性好,可用于熊果酸自微乳制剂的质量控制.
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| 关 键 词： | 熊果酸 自微乳 HPLC 含量 |
Determination of ursolic acid in self-microemulsifying drug delivery system by HPLC |
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| QIN Fu-hua,LIN Hang-juan,GAO Jian-qing. Determination of ursolic acid in self-microemulsifying drug delivery system by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2012, 0(9): 1257-1258 |
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| Authors: | QIN Fu-hua LIN Hang-juan GAO Jian-qing |
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| Affiliation: | 1. Zhejiang Pharmaceutical College,Ningbo 315100,China; 2. College of Pharmaceutical Science, Zhejiang University ,Hangzhou 310058, China) |
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| Abstract: | Objective To establish an HPLC method for the determination of ursolic acid in the self-microemulsifying drug delivery system. Methods Agilent TC-C18 column （250 mm × 4.6 mm,5 um） was used with a mobile phase of acetonitrile-0.3% phosphoric acid （85： 15） and flow＇ rate was 1.0 ml . min-1. The detection wavelength was at 210nm and the temperature at 30℃. Results Ursolic acid presented a good linear correlation in the range of 40 - 160 mg . L- 1 （ r = 0. 999 9）. The precision and recovery of method conformed to requirements. Conclusion The method is accurate and reproducible, which can be used for quality control of this preparation. |
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| Keywords: | ursolic acid self-microemulsifying HPLC content |
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