| 鬼针草总黄酮提取工艺中试研究 |
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| 引用本文： | 许慧,陈飞虎,邵旭,汤文建,刘建军,张晨晨.鬼针草总黄酮提取工艺中试研究[J].安徽医药,2012,16(6):738-740. |
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| 作者姓名： | 许慧 陈飞虎 邵旭 汤文建 刘建军 张晨晨 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032;合肥七星医药科技有限公司,安徽,合肥,230088 |
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| 基金项目： | 国家科技专项重大新药创制项目 |
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| 摘 要： | 目的对鬼针草总黄酮提取工艺进行研究,确定生产工艺路线,并进行中试生产初步试验,为工业生产打下基础。方法先以70%乙醇提取,再通过HPD100大孔树脂吸附纯化,最后用乙醇进行纯化;以提取物中总黄酮和金丝桃苷含量为考察指标,考察鬼针草的提取工艺。结果确定鬼针草总黄酮制备工艺路线,制得鬼针草总黄酮(总黄酮含量50%),平均产率为1%。结论该工艺稳定可行,适合于工业化大生产。
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| 关 键 词： | 鬼针草总黄酮 中试 大孔树脂 |
Pilot-scale study on extraction technology of total flavonoids of Bidens Bipinnata L. |
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| Institution: | XU Hui , CHEN Fei-hu , SHAO Xu, et al ( 1. School of Pharmacy,Anhui Medical University, Hefei 230032 ;2. Hefei Qixing Medicine and Technology Co. Ltd, Hefei 230088 ) |
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| Abstract: | Objective To explore a proper technology in extracting total flavonoids from Bidens Bipinnata L. , ascertain the production process, and make a preliminary study on pilot-scale process. Methods The flavonoids of Bidens Bipinnata L. were extracted with 70% ethanol and purifiied by HPD100 macroporous resin and ethanol with ultrasonic sequentially. Total flavonoids and hyperin were used as the evaluating criwri~,. Results Extracted with 70% ethanol and purified by HPD100 macroporous resin and ethanol with ultrasonic sequen- tially,the total noids of Bidens Bipinnata L. was above 50% and the average yield was 1%. Conclusion The optimized process in , highly efficient and suitable for industrial production. |
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| Keywords: | total of Bidens Bipinnata L pilot-scale macroporous resin |
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