| PI3K/Akt/mTOR信号通路与肿瘤 |
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| 引用本文： | 张丹丹,李庆林.PI3K/Akt/mTOR信号通路与肿瘤[J].安徽医药,2012,16(3):281-283. |
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| 作者姓名： | 张丹丹 李庆林 |
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| 作者单位： | 安徽中医学院·省部共建新安医学教育部重点实验室,安徽,合肥,230038;安徽中医学院·省部共建新安医学教育部重点实验室,安徽,合肥,230038 |
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| 基金项目： | 国家自然科学基金，安徽省自然科学基金 |
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| 摘 要： | 在近年来的肿瘤治疗中,靶向生物治疗逐渐成为研究的热点。该文就磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/the mammalian target of Rapamycin(mTOR),PI3K/Akt/mTOR]信号通路予以综述,重点包括PI3K/Akt/mTOR信号转导在肿瘤机制中作用以及肿瘤治疗过程中耐药性方面的关系等。
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| 关 键 词： | PI3K/Akt/Mtor 信号传导 耐药性 |
Role of PI3K/Akt/mTOR signal transduction in tumor |
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| ZHANG Dan-dan
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LI Qing-lin.Role of PI3K/Akt/mTOR signal transduction in tumor[J].Anhui Medical and Pharmaceutical Journal,2012,16(3):281-283. |
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| Authors: | ZHANG Dan-dan LI Qing-lin |
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| Institution: | (Key Laboratory of Xin’an Medicine,Ministry of Education,Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine,Anhui College of Traditional Chinese Medicine,Hefei 230038,China) |
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| Abstract: | In recent years,targeted biological therapy has become an issue.In this paper,phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/the mammalian target of Rapamycin(PI3K/Akt/mTOR) were reviewed.And in this review,the highlights are the role of PI3K/Akt/mTOR signal transduction in tumor cells and the relationship between drug resistances and PI3K/Akt/mTOR signal transduction during treatment. |
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| Keywords: | PI3K/Akt/mTOR signal transduction drug resistances |
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