Association between interleukin-10 gene polymorphism -592 (A/C) and peritoneal transport in patients undergoing peritoneal dialysis |
| |
Authors: | Lee Yueh-Ting Tsai Yu-Che Yang Yu-Kun Hsu Kuo-Tai Liao Shang-Chih Wu Chien-Hsing Cheng Ben-Chung Chen Jin-Bor Lee Chih-Hsiung Lee Chien-Te |
| |
Institution: | Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. |
| |
Abstract: | Aim: The aim of this analysis was to know whether these three cytokine polymorphisms, including interleukin‐6 (IL‐6; ?572 G/C), tumour necrosis factor‐α (TNF‐α; ?308 G/A), and IL‐10 (–592 A/C) have an effect on baseline peritoneal transport property and longitudinal evolution of peritoneal function. Methods: A total of 141 stable peritoneal dialysis (PD) patients with mean treatment duration of 84.4 ± 34.2 months were enrolled. We genotyped these three cytokine polymorphisms, together with clinical parameters that were included as factors affecting longitudinal change of property of peritoneal transport over the first 3 year period after commencing therapy. Results: There was no significant association between genotypes and baseline peritoneal transport property. The ?592 A/C polymorphism of IL‐10 was associated with longitudinal change of peritoneal transport. The ratio of D/P creatinine was significantly higher in patients with AA than those with CC/CA genotypes at 12 months (0.65 ± 0.11 vs 0.62 ± 0.09, P = 0.048) and 24 months (0.64 ± 0.12 vs 0.59 ± 0.09, P = 0.018). In addition, patients with increased peritoneal transport have greater frequency distribution of AA genotype and A allele. Logistic regression analysis revealed that ?592 A allele was an independent predictor for the increase in D/P creatinine over the first 12 month period (odds ratio: 2.482, P = 0.017). There was no correlation between either polymorphism of IL‐6 ?572 (G/C) or TNF‐α?308 (G/A) and longitudinal change of peritoneal function. Conclusions: Single nucleotide polymorphism of IL‐10 ?592 (A/C) was associated with longitudinal evolution of peritoneal transport rate in PD patients rather than the baseline peritoneal characteristics. |
| |
Keywords: | cytokine gene polymorphisms peritoneal dialysis peritoneal transport |
本文献已被 PubMed 等数据库收录! |
|