胃癌组织中HER-2表达及与血管生成的关系

目的探讨HER-2在胃腺癌组织中的表达及与血管生成的关系。方法采用免疫组化学法检测478例胃腺癌组织及49例癌旁组织中HER-2、VEGF和微血管密度(MVD)的表达。结果胃癌组织HER-2阳性表达率为10.9%(52/478),癌旁组织未见HER-2阳性表达,HER-2阳性表达与肿瘤部位、Lauren分型及分化程度显著相关(P0.05);VEGF在胃癌和癌旁组织中的阳性率分别为63.2%(302/478)和26.5%(13/49)(P0.01),VEGF表达与胃癌组织浸润深度、淋巴结转移、TNM分期、静脉侵犯显著相关(P0.05);MVD在胃癌组织与癌旁组织间有显著性差异(51.44±19.24)vs(34.28±14.74),P0.01)],MVD与分化程度、浸润深度、淋巴结转移、TNM分期、静脉侵犯显著相关(P0.01)。胃癌组织中HER-2表达与VEGF、MVD均呈显著正相关(P0.01),VEGF表达与MVD呈显著正相关(P0.01)。结论 HER-2表达可能与胃癌血管生成有关,值得进一步研究。

Expression of HER-2 and its relation to angiogenesis in gastric cancer

Objective To investigate the expression of HER-2 and its association with angiogenesis in gastric cancer.Methods The expression of HER-2,VEGF and MVD were detected by immunohistochemical technique in 478 cases of gastric adenocarcinoma and 49 cases of adjacent normal tissue specimens.Results The overexpression of HER-2 was detected in 52 of 478 gastric adenocarcinoma specimens（10.9%）,but not in adjacent normal tissue.HER-2 expression was significantly correlated with tumor location,the lauren type and the degree of differentiation（P0.05）.The positive rates of VEGF in gastric adenocarcinoma and adjacent normal tissue were respectively 63.2%（302/478） and 26.5%（13/49）（P0.01）.The expression of VEGF was significantly associated with the depth of tumor invasion,lymph node metastasis,TNM stage and venous invasion（P0.05）.The values of MVD were higher in gastric adenocarcinoma than those in adjacent tissue（P0.01）and were closely correlated with the degree of differentiation,the depth of tumor invasion,lymph node metastasis,TNM stage and venous invasion（P0.01）.The expression of HER-2 was positively related to the expression of VEGF and MVD while VEGF expression correlated with MVD（P0.01）.Conclusion HER-2 may be a useful marker for reflecting angiogenesis of gastric cancer,which deserves further study.