| 脑源性神经营养因子与脑缺血的研究进展 |
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| 引用本文： | 付美红,李海涛. 脑源性神经营养因子与脑缺血的研究进展[J]. 安徽医药, 2012, 16(6): 717-720 |
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| 作者姓名： | 付美红 李海涛 |
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| 作者单位： | 南京中医药大学药学院,江苏,南京,210009;南京中医药大学药学院,江苏,南京,210009 |
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| 基金项目： | 澳门科学技术发展基金资助项目 |
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| 摘 要： | 脑源性神经营养因子(brain derived neurotrophic factor,BDNF)是在脑内形成的一类神经营养因子。BDNF通过作用于其特异性受体TrkB、P75促进神经元的生长发育同时修复受损的神经元。BDNF对缺血性脑损伤的保护机制是通过下调钙离子浓度,减小Bax/Bcl-2比值,对抗NO毒性等途径实现的。该文介绍了BDNF的基本作用及其与脑缺血的相关作用研究,综述了BDNF的应用方法研究。
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| 关 键 词： | 脑源性神经营养因子 作用机制 脑缺血 应用研究 |
Advances in the research of BDNF with cerebral ischemia |
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| FU Mei-hong , LI Hai-tao. Advances in the research of BDNF with cerebral ischemia[J]. Anhui Medical and Pharmaceutical Journal, 2012, 16(6): 717-720 |
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| Authors: | FU Mei-hong LI Hai-tao |
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| Affiliation: | (College of Pharmacy,Nanjing Uiversity of Chinese Medicine,Nanjing 210009,China) |
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| Abstract: | Brain derived neurotrophic factor(BDNF) is a class of neurotrophic factor formed within the brain.BDNF promotes the growth and development of the neurons and repair the damaged neurons acting on its specific receptors TrkB and P75.BDNF plays a key role in ischemic damage protection mainly by eliminating oxygen-derived free radicals,reducing Bax/Bcl-2 ratio,regulating the low levels of ca2+ and against NO toxicity as well.This paper introduces the basic function of BDNF and the related research of BDNF on ischemic damage.The article reviews the research of the application methods of BDNF. |
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| Keywords: | BDNF mechanism cerebral ischemia application research |
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