丹红注射液对肾性高血压大鼠离体心脏心功能的影响

目的：观察丹红注射液对肾性高血压模型大鼠离体心脏心功能的影响。方法：30只采用双肾双狭方法制备肾性高血压模型成功的大鼠，随机分为模型组、维拉帕米组及丹红组，3组大鼠均断头取心脏，采用 Langendorff 离体心脏灌流法测定肾性高血压模型大鼠离体心脏在给予丹红注射液灌流10 min 前及灌流后0.5 h，1 h，2 h 左室内压力最大上升／下降速率（±LV dp ／dt max），左室舒张末期内径（Left Ventricular End －Diastolic Diameter，LVEDD），左室收缩末期内径（Left Ventricular End Systolic Diameter，LVESD），左室内压力峰值（Left Indoor Pressure Peak，LVSP）及左室射血分数（Left Ventric-ular Ejection Fraction，LVEF）。并以此评价丹红注射液对肾性高血压模型大鼠离体心脏心功能的影响。结果：在灌流丹红注射液2 h 时后可降低肾性高血压大鼠离体心脏±LV dp ／dt max、LVSP、LVEF，与模型组比较，P ＜0.05，差异有统计学意义；对 LVEDP 及 LVEDP 则无明显影响。结论：丹红注射液对肾性高血压大鼠离体心脏具有降低心脏做功的作用，这与其降低心肌收缩力、减轻心脏负荷而起到保护心肌和改善心功能有关。

Danhong Injection on in Vitro Heart Function of Renal Hypertensive Rats

To observe the Danhong injection on renal hypertension model of rats in vitro heart function.Methods: Thirty renal hypertension model rats made through double kidney double narrow method were randomly divided into model group,verapamil group and Danhong group.Rats in all three groups were beheaded and taken the heart,and the heart perfusion in vitro of Langendorff method was used to measure renal hypertensive model rat heart in vitro for 10 min before Dansheng injection perfusion and perfusion after 0.5,1,2 h left indoor pressure maximum increase/decrease rate (plus or minus ±LV dp/dtmax) (mmHg/s),left ventricular end-diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left indoor pressure peak (LVSP) and left ventricular ejection fraction (LVEF).And this evaluation Danhong injection on renal hypertension model of rat in vitro heart function.Results: Two hours after perfusion of Danhong injection,renal hypertensive rats in vitro heart ±LV dp/dtmax,LVSP,LVEF dropped,compared with model group,P<0.05,and there was significant difference.The LVEDD (and LVEDP showed no obvious influence.Conclusion: Danhong injection on renal hypertensive rats in vitro heart has the function of reducing heart work,and lowering myocardial contraction force,as well as reducing heart load and protecting the myocardium and improving heart function.