A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau |
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| Authors: | Namikoshi M Akano K Meguro S Kasuga I Mine Y Takahashi T Kobayashi H |
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| Affiliation: | Department of Ocean Sciences and Training Vessel Umitaka-maru, Tokyo University of Fisheries, Minato-ku, Tokyo 108-8477, Japan. namikosh@tokyo-u.fish.ac.jp |
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| Abstract: | A new macrocyclic trichothecene, 12,13-deoxyroridin E (1), and three known compounds, roridin E (2), verrucarin A (3), and verrucarin J (4), were obtained as cytotoxic components from the marine-derived fungus Myrothecium roridum, isolated in Palau. 12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant. |
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