Interventionelle Tumordestruktion durch thermische Verfahren

The aim of this article is to present interventional therapy methods based on thermal ablation, such as radiofrequency ablation (RFA), laser-induced thermotherapy (LITT) and microwave ablation (MWA) for palliative therapy of secondary malignant liver and lung tumors. This report provides information on data about local tumor control rates, survival data, progression-free survival (PFS) and complications. In liver metastases of colorectal carcinoma (CRC) the local tumor control rate is 85% for RFA, 95% for LITT and 93% for MWA, long-time survival is 22 months for RFA, 37 months for LITT and 32 months for MWA, progression-free survival is 84 months for RFA, 97 months for LITT and 93 months for MWA. Recent studies showed improved results with combined systemic and regional chemotherapy (e.g. TACE). Local recurrences of head and neck malignoma, lymph node infiltration and pelvic neoplasia are less frequent indications for tumor ablation.