Pharmacokinetics of 7-con-O-methylnogarol in patients with solid tumors |
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Authors: | M. L. Zanette U. Tirelli R. Sorio D. Zadro F. Figoli S. Monfardini M. D'Incalci |
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Affiliation: | (1) Centro di Riferimento Oncologico, Aviano (PN), Italy;(2) Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milano, Italy |
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Abstract: | Summary The pharmacokinetics of 7-con-O-methylnogarol were investigated by HPLC assay with fluorometric detection in nine cancer patients with normal hepatic and renal function, after a 2-h infusion of 160 or 200 mg/m2. The drug disappeared from plasma biexponentially with a mean elimination half-life of 38±3 h; the mean apparent volume of distribution and the plasma clearance were 805±91 l/m2 and 14±2 l/h per m2. Within 48 h of administration, urinary excretion of the drug and its metabolite 7-con-O-methyl-N-demethylnogarol accounted for 2%–15% and 0.1%–6% of the dose, respectively. Neither 7-con-O-methylnogarol nor its N-demethyl derivative was conjugated with glucuronic acid or sulfate in detectable amounts. |
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