| 四环素类药物的流动注射分析研究 |
| |
| 引用本文： | 刘万忠,姜红,杜爱珍. 四环素类药物的流动注射分析研究[J]. 药学学报, 1991, 26(5): 391-394 |
| |
| 作者姓名： | 刘万忠 姜红 杜爱珍 |
| |
| 作者单位： | 湖北省药品检验所，湖北省药品检验所，湖北省药品检验所 武汉 430064，武汉 430064，武汉 430064 |
| |
| 摘 要： | 四环素类(主要包括四环素、金霉素、土霉素、强力霉素及甲烯土霉素等)是一类应用较广的抗生素药物。其含量测定,国内外药典均采用微生物法。该方法虽能反映其生物效价,但也存在一些问题,如分析周期较长,方法的准确度不高,且在测定条件下(pH6.6,
|
| 关 键 词： | 四环素类 流动注射分析 流通型传感器 |
| 收稿时间： | 1990-01-24 |
DETERMINATION OF TETRACYCLINES BY FLOW INJECTION ANALYSIS |
| |
| WZ Liu,H Jiang and AZ Du. DETERMINATION OF TETRACYCLINES BY FLOW INJECTION ANALYSIS[J]. Acta pharmaceutica Sinica, 1991, 26(5): 391-394 |
| |
| Authors: | WZ Liu H Jiang AZ Du |
| |
| Affiliation: | Hubei Provincial Institute for Drug Control, Wuhan. |
| |
| Abstract: | An accurate, convenient and fast method was proposed for the determination of tetracyclines (tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline) and their preparations by flow injection detector based on tetracycline flow-through sensor. The parameters affecting the measurement were discussed. The detector can respond to tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline, at the same time. Their slopes are 51-55 mV/decade over the concentration range of 10(-2)-5 x 10(-5) mol/L at pH 1.5-3.5. The results obtained are in good agreement with those by biological assay (less than 3% deviation). One hundred samples can be determined in an hour. |
| |
| Keywords: | Tetracyclines Flow injection analysis Flow-through sensor |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
