''Gender gap'' in multiple sclerosis: magnetic resonance imaging evidence |
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Authors: | C. Pozzilli V. Tomassini F. Marinelli A. Paolillo C. Gasperini S. Bastianello |
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Affiliation: | Department of Neurological Sciences, University 'La Sapienza', Rome, Italy. carlo.pozzili@uniroma l.it |
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Abstract: | The authors evaluated the gender difference in the magnetic resonance imaging characteristics of the lesions occurring in the brain of 413 multiple sclerosis (MS) patients. Men had fewer contrast-enhancing lesions (P = 0.01), but a higher proportion of lesions evolving into 'black holes' (P = 0.001), when compared with women. Thus, our data indicate that men with MS are prone to develop less inflammatory, but more destructive lesions than women. This study results provides support for a modulation of the MS pathological changes by gender. |
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Keywords: | gender difference magnetic resonance imaging multiple sclerosis |
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