| 大肠埃希菌连续分离株耐药表型及复方磺胺甲(噁)唑耐药相关基因研究 |
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| 引用本文： | 王伟,糜祖煌,毛剑锋,徐伟珍.大肠埃希菌连续分离株耐药表型及复方磺胺甲(噁)唑耐药相关基因研究[J].中国抗生素杂志,2008,33(12). |
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| 作者姓名： | 王伟 糜祖煌 毛剑锋 徐伟珍 |
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| 作者单位： | 1. 丽水市人民医院,浙江,丽水,323000
2. 无锡市克隆遗传技术研究所,无锡,214026 |
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| 摘 要： | 目的了解临床分离的大肠埃希菌耐药性和复方磺胺甲噁唑(SMZ/TMP)耐药相关基因存在状况。方法测定临床连续分离的60株大肠埃希菌对19种抗菌药物的敏感性,采用聚合酶链反应(PCR)检测SMZ/TMP耐药相关基因(sul1、dfrA1、dfrA17)。结果60株中sul1、dfrA1、dfrA17基因阳性分别为34株(56.7%)、1株(1.7%)、35株(58.3%)。结论临床分离的大肠埃希菌多重耐药严重;复方磺胺甲噁唑耐药相关基因携带率高。
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| 关 键 词： | 大肠埃希菌 复方磺胺甲嗯唑 耐药基因 |
Study on drug resistance phenotype and drug resistance-related trimethoprim-sulfamethoxazole genes in continuous isolates from Escherichia coli |
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| Wang We,Mi Zu-huang,Mao Jian-feng,Xu Wei-zhen.Study on drug resistance phenotype and drug resistance-related trimethoprim-sulfamethoxazole genes in continuous isolates from Escherichia coli[J].Chinese Journal of Antibiotics,2008,33(12). |
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| Authors: | Wang We Mi Zu-huang Mao Jian-feng Xu Wei-zhen |
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| Institution: | Wang Wei1,Mi Zu-huang2,Mao Jian-feng1 and Xu Wei-zhen1 |
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| Abstract: | Objective To investigate the drug resistance and drug resistance-related trimethoprim-sulfamethoxazole genes in Excherichia coli. Method Microdilution tests were performed to detect susceptibility of 60 strains of Escherichia coli to 19 antimicrobial agents and drug resistance-related trimethoprim-sulfamethoxazole were detected by PCR.Result The positive rates of sul1,dfrA1 and dfrA17 genes in 60 clinical strains of Escherichia coli were 56.7%,1.7%,58.3%,respectively.Conclusions There are multiple-drug resistance and high positive rate of drug resistance-related trimethoprim-sulfamethoxazde genes in Escherichia coli isolated from the hospital. |
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| Keywords: | Escherichia coli Trimethoprim-sulfamethoxazole Resistant genes |
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