齐拉西酮与利培酮治疗精神分裂症对照研究

目的：探讨齐拉西酮与利培酮治疗精神分裂症的疗效和安全性。方法：将85例精神分裂症患者随机分为齐拉西酮组和利培酮组,进行为期8周的双盲对照研究。采用阳性与阴性症状量表（PANSS）和治疗中出现的症状量表（TESS）评定疗效和不良反应。结果：齐拉西酮有效率为80.2%,利培酮有效率为83.5%,二者差异无显著性。结论：齐拉西酮治疗精神分裂症疗效较好,与利培酮相当,但不良反应有所不同。

Control Study of Ziprasidone and Risperidone in Treatment of Schizophrenia

Objective： To evaluate the efficacy and side effect of ziprasidone and resperidone in the treatment of schizophrenia. Method：Eighty - five patients with schizopherenia were randomly divided into ziprasidone groups （n = 42） and resperidone group （n = 43） for 8 weeks. Both groups were assessed with the positive and negative symptoms scale （PANSS） and treatment emergent symptoms scale（TESS） to evaluate their efficacy and side effect. Results： Two drugs had similar efficacy in the treatment of schizophrenia . The response rate of ziprasidone is 80.2 % and of resperidone is 83.5 %. Conclusion. Ziprasidone is an effective antipsychotic drugs and have same efficacy with resperidone in the treatment of schizophrenia.