米氮平早期干预对轻度胰腺癌恶液质模型进食和营养状况的影响

目的:探讨抗抑郁药米氮平早期干预对轻度胰腺癌恶液质模型进食量和营养状况的影响.方法:21只胰腺癌裸鼠皮下移植瘤模型随机分为对照组(A组)、米氮平早期干预组(B组)、米氮平后期治疗组(C组),每组7只.B、C组分别在术后第1天和第10天开始以米氮平10mg/(kg.d),灌胃,术后第10、13、16天,3组动物分别腹腔注射吉西他滨(50mg/kg).术后第28天处死裸鼠,比较3组动物体质量、进食量、肿瘤体积、皮下脂肪和臂围的变化.结果:3组胰腺癌移植瘤体积、皮下脂肪和臂围无明显差异(P>0.05).第4周B组进食量显著高于A组和C组(P<0.05);第25天B组体质量(18.05g±0.68g)显著高于A组(17.24g±0.53g,P<0.05),稍高于C组(17.65g±0.60g,P>0.05).结论:米氮平早期干预能显著改善轻度胰腺癌相关恶液质模型的进食量,并能在一定程度上延缓恶液质进程.

Early treatment with mirtazapine improves food intake and nutritional status in a gemcitabine-induced mild cachexia mouse model with pancreatic cancer

AIM:To investigate the effect of early treatment with mirtazapine on food intake and nutritional status in a gemcitabine-induced mild cachexia mouse model with pancreatic cancer.METHODS:After a subcutaneous xenograft model of pancreatic cancer was established,21 xenograft nude mice were randomly and equally divided into control group,early mirtazapine treatment group and late mirtazapine treatment group.The two treatment groups were given 10 mg/(kg.d) mirtazapine once daily by oral gavage from day 1 and day 10 after transplantation,respectively.All animals were given 50 mg/kg of gemcitabine i.p.on days 10,13 and 16 after transplantation.All mice were sacrificed on day 28.Body weight,food intake,tumor size,subcutaneous fat,arm circumference and the time-effect relationship were compared among the three groups.RESULTS:There were no significant differences in tumor size,subcutaneous fat and arm circumference among the three groups(all P > 0.05).At week 4,food intake was significantly higher in the early mirtazapine treatment group than in the other two groups(both P < 0.05).The body weight(18.05 g ± 0.68 g) in the early mirtazapine treatment group was significantly higher than that in the control group(17.24 g ± 0.53 g,P < 0.05),but had no significant difference with that in the late mirtazapine treatment group(17.65 g ± 0.60 g,P > 0.05).CONCLUSION:Early treatment with mirtazapine significantly improves food intake in the Gemcitabine-induced mild cachexia mouse model with pancreatic cancer,it can also postpone the processes of cachexia to some extent.