亚临床甲状腺功能减退症患者血脂水平变化分析

目的分析亚临床甲状腺功能减退症（亚临床甲减）患者血脂水平变化及临床意义。方法测定52例亚临床甲减患者、60例健康对照组和55例临床甲减组的血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离四碘甲状腺原氨酸（FT4）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）水平，比较其结果的差异。结果与对照组相比：临床甲减组与亚临床甲减组的LDL—C、TSH明显升高，有非常显著性差异（P〈0．01）；临床甲减组的FT4、TC、TG明显升高，有非常显著性差异（P〈0．01）；亚临床甲减组的TC和临床甲减组的FT3升高，差异有显著性（P〈0．05）。与亚临床甲减组相比：临床甲减组的FT4、TC、TG明显升高，有非常显著性差异（P〈0．01），TSH、FT3升高，差异有显著性（P〈0．05）。各组的HDL-C差异无统计学意义。结论亚临床甲减可以引起血脂代谢异常，并且部分血脂指标接近临床甲减。

Variations of lipids in patients with subclinical hypothyroidism

Objective To analyze the variety and clinic signification of lipids in patients with subclinical hypothyr oidism. Methods The levels of TSH,FT3,FT4,TC,TG,LDL-C,HDL-C in 52 subclinical hypothyroidism patients,60 controls and 55clinical hypothyroidism patients were determined and compared. Results Compared with the control the levels of LDL-C,TSH in clinical hypothyroidism and subclinical hypothyroidism patiens were higher (P<0.01); the levels of FT4,TC, TG in clinical hypothyroidism patients were higher (P<0.01). The level of TC in subclinical hypothyroidism patiens and FT3 in clinical hypothyroidism patients was higher (P<0.05). Compared with subclinical hypothyroidism, the levels of FT4,TC, TG,TSH、FT3 in clinical hypothyroidism patiens was higher (P<0.01 or P<0.05). Conclusion The level of lipids in subclinical hypothyroidism patients is abnormal and it amy be close to clinical hypothyroidism.